A REVIEW OF NEMBUTAL ORAL LIQUID

Check Closely (1)pentobarbital will lower the extent or effect of fentanyl by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Modify Therapy/Check Carefully. Coadministration of fentanyl with CYP3A4 inducers could lead to some minimize in fentanyl plasma concentrations, lack of efficacy or, potentially, development of a withdrawal syndrome